WEIGHT MANAGEMENT PROPERTIES
Weight management is crucial for maintaining overall health and reducing the risk of chronic diseases such as diabetes, heart disease, and hypertension. It also supports better energy levels, mobility, and mental well-being, enhancing overall quality of life.
At ACARYON, we developed several assays to provide insights into weight management properties of your products
Whether it's probiotics, food ingredient, plant extracts, etc., our experts are here to help you uncover the full potential of your products.
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Let’s explore the potential of your product together.
REGULATION OF SATIETY HORMONES
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Satiety hormones play a key role in weight management by regulating appetite and food intake, signaling fullness to the brain and helping maintain energy balance.
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Orally taken products may improve the release of satiety hormones.
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The STC-1 cell line is a well established model used to analyse the production of the main appetite regulating hormones GLP-1, PYY, CCK and GIP.
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We analyse the effect of your product on the production of the main satiety hormones in the context of the STC-1 model.
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Various testing conditions can be selected based on your needs.
LIPID ACCUMULATION
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Adipocytes play a crucial role in weight management and participate in long-term appetite regulation. The lipids that accumulate in adipocytes serve as the body's primary energy storage. However, excessive accumulation can lead to obesity, metabolic dysfunction, and insulin resistance.
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Adipocytes also produce leptin, a hormone signaling the brain to reduce food intake and increase energy expenditure when fat stores are sufficient.
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Based on the 3T3 cell line model we analyse the effect of your product on lipid accumulation and the production of leptin
CHOLESTEROL AND FATTY ACID BIDNING
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High level of triglyceride and/or cholesterol are among the most significant risk factors for cardiovascular disease.
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Orally taken products may decrease the triglyceride and/or cholesterol level via various mechanisms.
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We have established assays to analyse direct cholesterol or fatty acid binding in the gut, as well as microbiome modulation that impacts lipid metabolism..
MICROBIOME MODULATION
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Microbiome modulation can support weight management by influencing metabolism, appetite regulation and fat storage through the production of bioactive compounds and interactions with the gut-brain axis. A balanced gut microbiome may enhance nutrient absorption, reduce inflammation and improve insulin sensitivity, contributing a healthier weight control.
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Modulating the gut microbiome composition presents an exciting strategy for effective weight management.
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With the HUMIPLATE platform, we offer a comprehensive analysis of your product’s effect on the microbiome. The supernatant of microbiome cultures can be tested for antimicrobial properties, helping identify its potential to modulate microbiome activity and support optimal weight management.
Have a non-binding consultation with one of our experts to find out the best solution for your needs.
Book a discussion slot or contact us.
