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IMMUNOMODULATORY PROPERTIES
Our immune system is essential to prevent and combat infections and diseases. A disbalanced immune system can lead to serious health problems, such as chronic inflammation, increasing the risk of conditions like allergies, diabetes and cardiovascular diseases.
There are many ways in which products can directly or indirectly modulate the immune system.
At ACARYON we have developed a wide range of assays allowing to get insights into the immunomodulatory properties of your products.
Whether probiotics, food ingredient, plant extracts etc., our experts are here to help you uncover the full potential of your products.
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Let’s explore the potential of your products together.
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CYTOKINE PROFILING OF INTESTINAL CELLS
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A product acts on the intestinal cells, inducing the local production of immune factors (e.g. cytokines).
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Cytokines regulate the homeostasis and function of immune cells. Pro-inflammatory cytokines alert the immune system to potential danger, anti-inflammatory cytokines avoid overreaction and allow wound healing.
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We analyse the effect of your product on the cytokine production profile of the gut epithelium under physiological conditions.
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Alternatively, conditions of inflammation, bacterial or viral infection can be simulated.
MACROPHAGE PRIMING​
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Macrophages are crucial for immune regulation as they help orchestrate the immune response by recognizing and eliminating pathogens while also secreting cytokines that influence other immune cells. They can shift between pro-inflammatory and anti-inflammatory states, ensuring a balanced response to infection and promoting tissue healing
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Macrophages populations can be directed toward M1 (pro-inflammatory) and M2 (anti-inflammatory) phenotypes. In the steady state, macrophages predominantly exhibit an M2 phenotype.
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We analyse the direct and/or indirect effect of your product on the polarisation of immature macrophages (indirect may mean via modulation of the human microbiome).
MACROPHAGE PHAGOCYTIC ACTIVITY
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Macrophages play a crucial role in defending the host against infection and orchestrating the immune response.
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Their phagocytic activity is center to their role in maintaining homeostasis.
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We analyse the direct and/or indirect effect of your product on the phagocytic capacity of macrophages (indirect may mean via modulation of the human microbiome).
MICROBIOME MODULATION
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The microbiome is a key regulator of the immune system. It educates immune cells, promoting tolerance to beneficial microbes, modulating inflammatory responses through microbial metabolites and interactions with gut-associated lymphoid tissue and much more.
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With the HUMIPLATE platform, you can unlock critical insights into how your product influences these immunemodulatory properties.
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By analysing the supernatant of microbiomes cultivated with your product, HUMIPLATE reveals its impact on microbiome-driven immune modulation.
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Discover the immune-boosting potential of your innovations with cutting-edge precision!
Have a non-binding consultation with one of our experts to find out the best solution for your needs.
Book a discussion slot or contact us.
